Messenger RNA regulation during compensatory renal growth
نویسندگان
چکیده
منابع مشابه
Messenger RNA in Compensatory Renal Hypertrophy
Experiments that deal with the stability of messenger RNA (mRNA) in normal mouse kidney, and, to some extent, the stability of mRNA during renal growth will be described. We have found a population of mRNA in the cytoplasm of mouse kidney that is short-lived. Such a class of rapidly metabolized mRNA could play an adaptive role at the translational or cytoplasmic level in determining gene expres...
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After removal of one mouse kidney, compensatory hypertrophy in the remaining kidney is marked in 2 days by a 20% average increase in ribosomal RNA (rRNA) per cell. Both 28S and 18S RNA are conserved during the initial stages of compensatory renal hypertrophy to an extent sufficient to account for the rest of the observed accumulation of rRNA. Like some cultured cells, the kidney conserves rRNA ...
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Transcriptional regulation has been a dominant area of research in gene expression for more than 50 years. However, the past 20 years of research in biology brought new focus on posttranscriptional events, namely RNA regulation. This emphasis on understanding the regulatory functions of RNAs emerged with the identification of cisand trans-regulatory regions in pre-mRNAs and mature mRNAs, noncod...
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Compensatory renal growth after unilateral ureteral obstruction. The accumulation of bulk renal protein, RNA and DNA was studied in mice during a 35-day period of accelerated renal growth in the kidney contralateral to that obstructed by acute ureteral ligation. Control mice were sham-operated and nonoperated. RNA was determined by the method of Monroe and Fleck, DNA after Ceriotti and protein ...
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SILBER, SHERMAN, AND RICHARD L. MALVIN. Compensatory and obligatory renal growth in rats. Am. J. Physiol. 226(l) : 114-l 17. 1974.-Renal size and function were studied in three groups of rats in an attempt to gain information relating to the control of renal size. One group consisted of normal rats into which a third kidney was transplanted; a second group consisted of unilaterally nephrectomiz...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1983
ISSN: 0085-2538
DOI: 10.1038/ki.1983.60